Positions
- Professor
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Department of Neuroscience
Departments of Molecular and Cellular Biology, Neurology, and Neurosurgery
在线黑料门
Houston, TX
- Associate Director
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Graduate Program in Neuroscience
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- Faculty Member
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Graduate Programs in Neuroscience and Development, Disease Models, and Therapeutics (DDMT)
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- Vivan L. Smith Endowed Chair in Neuroscience
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Baylor College Of Medicine
Addresses
- Department of Neuroscience (Lab)
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在线黑料门
Houston, TX 77030
United States
Education
- BA from Amherst College
- 06/1991 - Amherst, Massachusetts United States
- Biology
- PhD from California Institute Of Technology
- 06/1999 - Pasadena, California United States
- Molecular and Cellular Neuroscience
- Advanced Training from Johns Hopkins University School Of Medicine
- 01/2003 - Baltimore, MD United States
Professional Statement
Our research focuses on the pathogenesis of Alzheimer鈥檚 disease. Broadly speaking, we want to understand factors that influence disease risk and dictate the stereotyped loss of neural circuits needed for memory. More specifically, we want to understand how aging increases the likelihood of dementia, how genetics may influence this risk, and how specific brain areas are selectively affected.Our laboratory uses transgenic mice as a model system that can be engineered to reproduce focused aspects of the disease. These models allow us to test cellular and molecular hypotheses about causes and consequences of disease pathology, and to define how interactions between genes, environment, and aging determine resilience or risk.
We are currently pursuing three avenues of study. One project explores the genetic basis of cognitive reserve by engineering mice to express a gene variant associated with preserved cognition in patients with Alzheimer's neuropathology. Complementary studies examine how brain aging contributes to Alzheimer's risk using mice designed to stop time through exogenous control of amyloid onset. Finally, we are investigating the basis for progressive neuronal vulnerability in Alzheimer's using mice created to test whether circuit function contributes to disease susceptibility. Our hope is that mice and men share sufficient similarities in genetic architecture, basic physiology, and neuronal circuitry to gain insight from one useful in understanding the other.
Key questions:
1. How do genetics influence whether individuals with amyloid pathology will progress to dementia or remain cognitively healthy?
2. How does aging contribute to AD? Why does this disease primarily strike late in life?
3. What makes neurons of the entorhinal cortex particularly vulnerable in AD? Might their normal role in episodic memory contribute to their frailty in disease?
Websites
Selected Publications
- Nguyen, Q. Wood, C.A., Kim, P.J, and Jankowsky, J.L. "." Front. Neurosci.. 2023; Pubmed PMID:
- 50. Zhang, T., Pang, W., Feng, T., Guo, J., Wu, K., Nunez Santos, M., Arthanarisami, A., Nana, A.L., Nguyen, Q., Kim, P.J., Jankowsky, J.L., Seeley, W.L., Hu, F. "." Sci Adv. 2023; Pubmed PMID:
- 48. Koller, E.J., Comstock, M., Bean, J.C., Escobedo, G., Park, K.-W., Jankowsky, J.L. "." 2022; Pubmed PMID:
- 49. Zhao, R.*, Grunke, S.D.*, Wood, C.A.*, Perez, G.A., Comstock, M., Li, M.-H., Singh, A.K., Park, K.-W., Jankowsky, J.L. "." eLife. 2022; Pubmed PMID:
- Park, K.-W., Wood, C.A., Li, J., Taylor, B.C., Oh, S.-W., Young, N.L, and Jankowsky, J.L. "." Mol. Ther.. 2021; Pubmed PMID:
- Roy ER, Wang B, Wan YW, Chiu G, Cole A, Yin Z, Propson NE, Xu Y, Jankowsky JL, Liu Z, Lee VM, Trojanowski JQ, Ginsberg SD, Butovsky O, Zheng H, Cao W. "." J. Clin. Invest.. 2020;130:1912-1930. Pubmed PMID:
- Huichalaf, C.H., Al-Ramahi, I.*, Park, K.W.*, Grunke, S.D., Lu, N., de Haro, M., El-Zein, K., Gallego-Flores, T., Perez, A.M., Jung, S.Y., Botas, J., Zoghbi, H.Y., and Jankowsky, J.L. "." Hum. Mol. Genet.. 2019;28:2014-2029. Pubmed PMID:
- Lillehaug, S., Yetman, M.J., Puchades, M.A., Checinska, M.M, Kleven, H., Jankowsky, J.L., Bjaalie, J.G., and Leergaard, T.B. "." Sci. Data. 2019;6:190028. Pubmed PMID:
- Chiang, A.C-A., Fowler, S.W., Savjani, R.R., Hilsenbeck, S.G., Wallace, C.E., Cirrito, J.R., Das, P. and Jankowsky, J.L. "." J. Exp. Med. 2018;215:1349-1364. Pubmed PMID:
- Chiang, A.C.A.*, Fowler, S.W.*, Reddy, R., Pletnikova, O., Troncoso, J.C., Sherman, M.A., Lesne, S., and Jankowsky, J.L. "Discrete pools of oligomeric amyloid-尾 track with spatial learning deficits in a mouse model of Alzheimer's amyloidosis." Am. J. Pathol.. 2017;
- Verbeeck, C.*, Carrano, A.*, Chakrabarty, P., Jankowsky, J.L., and Das, P. "." Am. J. Pathol.. 2017; Pubmed PMID:
- Zheng, H. and Jankowsky, J.L. "." Mol Neurodegener.. 2017;12(1):89. Pubmed PMID:
- Kim, J-Y., Jang, A., Reddy, R., Yoon, W.H., Jankowsky, J.L. "." Hum. Mol. Genet.. 2016;25:4661-4673. Pubmed PMID:
- Zhao, R., Grunke, S.D., Keralapurath, M.M., Yetman, M.J., Lam, A., Lee, T.C., Jiang, Y., Swing, D.A., Tessarollo, L., Ji, D., and Jankowsky, J.L. "." Cell Repts.. 2016;16:1-12. Pubmed PMID:
- Lian, H. Litvinchuk, A., Chiang, A.C.-A., Aithmitti, N., Jankowsky, J.L., and Zheng, H. "." J. Neurosci.. 2016;36:577-589. Pubmed PMID:
- Marin, M.A., Ziburkus, J., Jankowsky, J.L., and Rasband, M.N. "Amyloid-尾 plaques disrupt axon initial segments." Exp. Neurol.. 2016;281:93-98.
- Yetman, M.J., Fowler, S.W., and Jankowsky, J.L. "." PLoS ONE :. 2016;11:e0153724. Pubmed PMID:
- Kim, J.-Y.*, Grunke, S.D.*, and Jankowsky, J.L. "." Method. Mol. Biol.. 2016; Pubmed PMID:
- Liu P, Reed MN, Kotilinek LA, Grant MK, Forster CL, Qiang W, Shapiro SL, Reichl JH, Chiang AC, Jankowsky JL, Wilmot CM, Cleary JP, Zahs KR, Ashe KH "." Cell Repts. 2015; Pubmed PMID:
- Lian H, Yang L, Cole A, Sun L, Chiang AC, Fowler SW, Shim DJ, Rodriguez-Rivera J, Taglialatela G, Jankowsky JL, Lu HC, Zheng H "." Neuron. 2015;85(1):101-15. Pubmed PMID:
- Wang J, Wegener JE, Huang TW, Sripathy S, et al. "." Nature. 2015;521(7552):E1-4. Pubmed PMID:
- Yetman MJ, Lillehaug S, Bjaalie JG, Leergaard TB, Jankowsky JL "." Brain Struct. Funct.. 2015; Pubmed PMID:
- Kim, J.-Y.*, Grunke, S.D.*, Levites, Y., Golde, T.E., and Jankowsky, J.L. "Intracerebroventricular viral injection for widespread transduction of the neonatal mouse brain." J. Vis. Exp..;
- Fowler, S.W.*, Chiang, A. C-A.*, Savjani, R.R., Larson, M.E., Schuler, D.R., Cirrito, J.R., Lesne, S., and Jankowsky, J.L. "." J. Neurosci.. 2014;34:7871-7885. Pubmed PMID:
- Zhao R, Fowler SW, Chiang AC, Ji D, Jankowsky JL "." Hippocampus. 2014;24:963-78. Pubmed PMID:
- Born HA, Kim JY, Das P, Dabaghian Y, Guo Q, Yoo JW, Schuler DR, Cirrito JR, Zheng H, Golde TE, Noebels JL, Jankowsky JL "." J. Neurosci. 2014;34:3826-40. Pubmed PMID:
- Sun MY, Yetman MJ, Lee TC, Chen Y, Jankowsky JL "." J. Comp. Neurol. 2014;522:1191-1208. Pubmed PMID:
- Tanifum, E.A., Starosolski, Z.A., Ghaghada, K., Fowler, S.W., Jankowsky, J.L. "Computed tomography for detection of vascular leak in a mouse model of amyloid neuropathology." J. Cereb. Blood Flow Metab..;
- Kim JY, Ash RT, Ceballos-Diaz C, Levites Y, Golde TE, Smirnakis SM, Jankowsky JL "." Eur. J. Neurosci.. 2013 Apr;37(8):1203-20. Pubmed PMID:
- Yetman MJ, Jankowsky JL "." J. Neurosci. 2013;33:17335-41. Pubmed PMID:
- Chakrabarty, P., Rosario, A., Cruz, P., Siemienski, Z., Ceballos-Diaz, C., Crosby, K., Jansen, K., Borchelt, D.R., Kim, J.-Y., Jankowsky, J.L., Golde, T.E., and Levites, Y. "." PLoS ONE. 2013;8:e67680. Pubmed PMID:
- Rodgers SP, Born HA, Das P, Jankowsky JL "." Mol Neurodegener. 2012;7:28. Pubmed PMID:
- Han HJ, Allen CC, Buchovecky CM, Yetman MJ, Born HA, Marin MA, Rodgers SP, Song BJ, Lu HC, Justice MJ, Probst FJ, Jankowsky JL "." J. Neurosci.. 2012 Aug 1;32(31):10574-86. Pubmed PMID:
- Cowin RM, Roscic A, Bui N, Graham D, Paganetti P, Jankowsky JL, Weiss A, Paylor R "." Behav. Brain Res.. 2012 Apr 15;229(2):308-19. Pubmed PMID:
- Wang A, Das P, Switzer RC, Golde TE, Jankowsky JL "." J. Neurosci.. 2011 Mar 16;31(11):4124-36. Pubmed PMID:
- Badea A, Johnson GA, Jankowsky JL "." Neuroimage. 2010 Apr 1;50(2):416-27. Pubmed PMID:
- Moss FJ, Imoukhuede PI, Scott K, Hu J, Jankowsky JL, Quick MW, Lester HA "." J. Gen. Physiol.. 2009 Dec;134(6):489-521. Pubmed PMID:
- Verret L, Jankowsky JL, Xu GM, Borchelt DR, Rampon C "." J. Neurosci.. 2007 Jun 20;27(25):6771-80. Pubmed PMID:
- Jankowsky JL, Younkin LH, Gonzales V, Fadale DJ, Slunt HH, Lester HA, Younkin SG, Borchelt DR "." J. Biol. Chem.. 2007 Aug 3;282(31):22707-20. Pubmed PMID:
- Jankowsky JL, Melnikova T, Fadale DJ, Xu GM, Slunt HH, Gonzales V, Younkin LH, Younkin SG, Borchelt DR, Savonenko AV "." J. Neurosci.. 2005 May 25;25(21):5217-24. Pubmed PMID:
- Jankowsky JL, Slunt HH, Gonzales V, Savonenko AV, Wen JC, Jenkins NA, Copeland NG, Younkin LH, Lester HA, Younkin SG, Borchelt DR "." PLoS Med.. 2005 Dec;2(12):e355. Pubmed PMID:
- Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK, Younkin LH, Wagner SL, Younkin SG, Borchelt DR "." Hum. Mol. Genet.. 2004 Jan 15;13(2):159-70. Pubmed PMID:
- Jankowsky JL, Slunt HH, Gonzales V, Jenkins NA, Copeland NG, Borchelt DR "." Neurobiol. Aging. 2004 Aug;25(7):885-92. Pubmed PMID:
- Jankowsky JL, Xu G, Fromholt D, Gonzales V, Borchelt DR "." J. Neuropathol. Exp. Neurol.. 2003 Dec;62(12):1220-7. Pubmed PMID:
- Jankowsky JL, Savonenko A, Schilling G, Wang J, Xu G, Borchelt DR "." Curr Neurol Neurosci Rep. 2002 Sep;2(5):457-64. Pubmed PMID:
- Jankowsky JL, Slunt HH, Ratovitski T, Jenkins NA, Copeland NG, Borchelt DR "." Biomol. Eng.. 2001 Jun;17(6):157-65. Pubmed PMID:
- Lesuisse C, Xu G, Anderson J, Wong M, Jankowsky J, Holtz G, Gonzalez V, Wong PC, Price DL, Tang F, Wagner S, Borchelt DR "." Hum. Mol. Genet.. 2001 Oct 15;10(22):2525-37. Pubmed PMID:
- Jankowsky JL, Patterson PH "." Prog. Neurobiol.. 2001 Feb;63(2):125-49. Pubmed PMID:
- Jankowsky JL, Patterson PH "." Mol. Cell. Neurosci..;14(41369):273-86. Pubmed PMID:
- Jankowsky JL, Derrick BE, Patterson PH "." Learn. Mem..;7(6):400-12. Pubmed PMID:
- Jankowsky JL, Patterson PH "." Exp. Neurol.. 1999 Oct;159(2):333-46. Pubmed PMID:
- Edwards GA 3rd, Wood CA, He Y, Nguyen Q, Kim PJ, Gomez-Gutierrez R, Park KW, Xu Y, Zurhellen C, Al-Ramahi I, Jankowsky JL "." Acta Neuropathol. 2024; Pubmed PMID:
- Koller EJ, Wood CA, Lai Z, Borgenheimer E, Hoffman KL, Jankowsky JL. "." J Neuroinflammation. 2024; Pubmed PMID:
- Perez GA, Park KW, Lanza D, Cicardo J, Uddin MD, Jankowsky JL. "." Genesis. 2023; Pubmed PMID:
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