在线黑料门

Department of Surgery

  1. 在线黑料门
  2. Departments
  3. Surgery
  4. Research
  5. Laboratory for Cardiac Regeneration
  6. Cardiac Regeneration Lab Publications

Cardiac Regeneration Lab Publications

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publications

. publications

Selected articles

  1. Riham R E Abouleisa, Xian-Liang Tang, Qinghui Ou, Abou-Bakr M Salama, Amie Woolard, Dana Hammouri, Hania Abdelhafez, Sarah Cayton, Sameeha K Abdulwali, Momo Arai, Israel D Sithu, Daniel J Conklin, Roberto Bolli, Tamer M A Mohamed, Gene therapy encoding cell cycle factors to treat chronic ischemic heart failure in rats, Cardiovascular Research, 2024;, cvae002.
  2. Tamer M. A. Mohamed*, Riham Abou-Leisa, Nicholas Stafford, Arfa Maqsood, Min Zi, Sukhpal Prehar, Florence Baudoin-Stanley, Xin Wang, Elizabeth J. Cartwright, Ludwig Neyses, Delvac Oceandy. The Plasma Membrane Calcium ATPase 4 Signaling in Cardiac Fibroblasts Mediates Cardiomyocyte Hypertrophy.  Nature Communications, 2016 Mar 29;7:11074. 
  3. Yen-Sin Ang, Renee N. Rivas, Alexandre J.S. Ribeiro, Rohith Srivas, Janell Rivera, Nicole R. Stone, Karishma Pratt, Tamer M. A. Mohamed, Ji-Dong Fu, C. Ian Spencer, Nathaniel D. Tippens, Molong Li, Anil Narasimha, Ethan Radzinsky, Anita J. Moon-Grady, Haiyuan Yu, Beth L. Pruitt, Michael P. Snyder, Deepak Srivastava. Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis. Cell. 2016 Dec 15;167(7):1734-1749.e22.
  4. Abigail Robertson, Tamer M. A. Mohamed, Zeinab El Maadawi, Nicholas Stafford, ThuyBui, Dae-Sik Lim, Elizabeth J. Cartwright, Delvac Oceandy Genetic ablation of the mammalian sterile-20 like kinase 1 (Mst1) improves cell reprogramming efficiency and increases induced pluripotent stem cell proliferation and survival. Stem Cell Res. 2017 Apr;20:42-49
  5. Tamer M. A. Mohamed*, Nicole Stone, Ethan Radzinsky, Pengzhi Yu, Yu Huang, Haixia Wang, Sheng Ding, Deepak Srivastava. Chemical Enhancement of Direct Cardiac Reprogramming In Vitro and In Vivo. Circulation. 2017 Mar 7;135(10):978-995. 
  6. Tamer M A Mohamed*, Yen-Sin Ang, Ethan Radzinsky, Ping Zhou, Yu Huang, Ary茅 Elfenbein, Amy Foley, Sergey Magnitsky, Deepak Srivastava. Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration. Cell. 2018 Mar 22;173 (1):104鈥116  
  7. Nicole Stone, Casey Gifford, Reuben Thomas, Karishma Pratt, Kaitlin Samse-Knapp, Tamer M A Mohamed, Ethan Radzinsky, Amelia Schricker, Lin Ye, Palmer Yu, Joke van Bemmel, Kathy Ivey, Katherine Pollard, Deepak Srivastava Context-Specific Transcription Factor Functions Regulate Epigenomic and Transcriptional Dynamics during Cardiac Reprogramming. Cell Stem Cell. 2019 Jul 3;25(1):87-102.
  8. Qinghui Ou, Zo毛 Jacobson, Riham R E Abouleisa, Xian-Liang Tang, Sajedah M. Hindi, Ashok Kumar, Kathryn N. Ivey, Guruprasad Giridharan, Ayman Al-Baz, Kenneth Brittian, Benjamin Rood, Bradford G. Hill, Steven P. Jones, Roberto Bolli, Tamer M A Mohamed*. A Physiological Biomimetic Culture System for Pig and Human Heart Slices. Circulation Research. 2019 Aug 30;125(6):628-642. 
  9. Qinghui Ou, Riham R E Abouleisa, Xian-Liang Tang, Hamzah R Juhardeen, Moustafa H Meki, Jessica M Miller, Guruprasad Giridharan, Ayman El-Baz, Roberto Bolli, Tamer M A Mohamed*. Slicing and Culturing Pig Hearts Under Physiological Conditions J Vis Exp. 2020 Mar 20;(157). 
  10. Jessica M Miller, Moustafa H Meki, Qinghui Ou, Sharon A George, Anna Gams, Riham R E Abouleisa, Xian-Liang Tang, Brooke M Ahern, Guruprasad A Giridharan, Ayman El-Baz, Bradford G Hill, Jonathan Satin, Daniel J Conklin, Javid Moslehi, Roberto Bolli, Alexandre J S Ribeiro, Igor R Efimov, Tamer M A Mohamed*. Heart slice culture system reliably demonstrates clinical drug-related cardiotoxicity Toxicol Appl Pharmacol 2020 Aug 30;406:115213. 
  11. Riham Abouleisa, Lindsey McNally, Abou bakr Mohamed Salama, Sally K. Hammad, Qinghui Ou, Collin Wells, Pawel K. Lorkiewicz, Roberto Bolli, Tamer M.A. Mohamed* and Bradford G. Hill* Cell cycle induction in human cardiomyocytes is dependent on biosynthetic pathway activation Redox Biol. 2021 Oct;46:102094. 
  12. Riham R E Abouleisa, Abou Bakr M Salama, Qinghui Ou, Xian-Liang Tang, Mitesh Solanki, Yiru Guo, Yibing Nong, Lindsey McNally, Pawel K Lorkiewicz, Kamal M Kassem, Brooke M Ahern, Krishna Choudhary, Reuben Thomas, Yu Huang, Hamzah R Juhardeen, Aisha Siddique, Zainab Ifthikar, Sally K Hammad, Ayman S El-Baz, Kathryn N Ivey, Daniel J Conklin, Jonathan Satin, Bradford G Hill, Deepak Srivastava, Roberto Bolli, Tamer M A Mohamed*.  Transient Cell Cycle Induction in Cardiomyocytes to Treat Subacute Ischemic Heart Failure. Circulation, 2022 Apr 26;145(17):1339-1355 
  13. Jessica M. Miller, Moustafa H. Meki, Ahmed Elnakib, Qinghui Ou, Riham R. E. Abouleisa, Xian-Liang Tang, Abou Bakr M. Salama, Ahmad Gebreil, Cindy Lin, Hisham Abdeltawab, Fahmi Khalifa, Bradford G. Hill, Najah Abi-Gerges, Roberto Bolli, Ayman S. El-Baz, Guruprasad A. Giridharan, Tamer M. A. Mohamed. Biomimetic Cardiac Tissue Culture Model (CTCM) to Emulate Cardiac Physiology and Pathophysiology ex vivo. Nature Communications Biology, 2022 Sep 9;5(1):934. 
  14. Huanyu Zhou, Jin Yang, Chetan Srinath, Aliya Zeng, Iris Wu, Elena C Leon, Tawny Neal Qureshi, Christopher A Reid, Emily R Nettesheim, Emma Xu, Zoe Duclos, Tamer M A Mohamed, Farshad Farshidfar, Anthony Fejes, Jun Liu, Samantha Jones, Charles Feathers, Tae Won Chung, Frank Jing, William S Prince, JianMin Lin, Pengzhi Yu, Deepak Srivastava, Timothy Hoey, Kathryn N Ivey, Laura M Lombardi. Improved Cardiac Function in Postischemic Rats Using an Optimized Cardiac Reprogramming Cocktail Delivered in a Single Novel Adeno-Associated Virus. Circulation 2023 Aug 21.
  15. Riham Abouleisa, Jessica Miller, Ahmed Gebreil, Abou Bakr Salama, Marc Dwenger, Hania Abdelhafez, Reham Wahid, Adeniyi Adewumi, Mahmoud E. Soliman, Nader Abo-Dya, Tamer M A Mohamed. A Novel Small Molecule Inhibitor of p38鈲 MAP Kinase Augments Cardiomyocyte Cell Cycle Entry in Response to Direct Cell Cycle Stimulation. Br J Pharmacol. 2023 Aug 7. 
  16. Cindy Y. Kok, Shinya Tsurusaki, Marti Cabanes-Creus, Sindhu Igoor, Renuka Rao, Rhys Skelton, Sophia H.Y. Liao, Samantha L. Ginn, Maddison Knight, Suzanne Scott, Mario Mietzsch, Rebecca Fitzsimmons, Jessica Miller, Tamer M. A. Mohamed, Robert McKenna, James J.H. Chong, Adam P. Hill, James E. Hudson, Ian E. Alexander, Leszek Lisowski, Eddy Kizana Development of new adeno-associated virus capsid variants for targeted gene delivery to human cardiomyocytes. Molecular Therapy Methods and Clinical Development 30, P459-473, Sept. 14, 2023.
  17. Rosengart TK. Cardiac cellular reprogramming. Tex Heart Inst J. 2013;40(5):581-2. PMID: 24391328; PMCID: PMC3853848.
  18. Brlecic PE, Bonham CA, Rosengart TK, Mathison M. Direct cardiac reprogramming: A new technology for cardiac repair. J Mol Cell Cardiol. 2023 May;178:51-58. doi: 10.1016/j.yjmcc.2023.03.008. Epub 2023 Mar 23. PMID: 36965701; PMCID: PMC10124164.
  19. Patel V, Mathison M, Singh VP, Yang J, Rosengart TK. Direct Cardiac Cellular Reprogramming for Cardiac Regeneration. Curr Treat Options Cardiovasc Med. 2016 Sep;18(9):58. doi: 10.1007/s11936-016-0480-8. PMID: 27554127; PMCID: PMC5278776.
  20. Rosengart TK, Patel V, Sellke FW. Cardiac stem cell trials and the new world of cellular reprogramming: Time to move on. J Thorac Cardiovasc Surg. 2018 Apr;155(4):1642-1646. doi: 10.1016/j.jtcvs.2017.11.104. Epub 2017 Dec 26. PMID: 29397153; PMCID: PMC5860963.
  21. Ryan CT, Patel V, Rosengart TK. Clinical potential of angiogenic therapy and cellular reprogramming. JTCVS Open. 2021 Jun;6:108-115. doi: 10.1016/j.xjon.2020.12.023. Epub 2021 Mar 18. PMID: 34746874; PMCID: PMC8570572.
  22. Patel V, Singh VP, Pinnamaneni JP, Sanagasetti D, Olive J, Mathison M, Cooney A, Flores ER, Crystal RG, Yang J, Rosengart TK. p63 Silencing induces reprogramming of cardiac fibroblasts into cardiomyocyte-like cells. J Thorac Cardiovasc Surg. 2018 Aug;156(2):556-565.e1. doi: 10.1016/j.jtcvs.2018.03.162. Epub 2018 Apr 13. PMID: 29716728; PMCID: PMC6050095.
  23. Singh VP, Pinnamaneni JP, Pugazenthi A, Sanagasetti D, Mathison M, Martin JF, Yang J, Rosengart TK. Hippo Pathway Effector Tead1 Induces Cardiac Fibroblast to Cardiomyocyte Reprogramming. J Am Heart Assoc. 2021 Dec 21;10(24):e022659. doi: 10.1161/JAHA.121.022659. Epub 2021 Dec 10. PMID: 34889103; PMCID: PMC9075224.
  24. Singh VP, Pinnamaneni JP, Pugazenthi A, Sanagasetti D, Mathison M, Wang K, Yang J, Rosengart TK. Enhanced Generation of Induced Cardiomyocytes Using a Small-Molecule Cocktail to Overcome Barriers to Cardiac Cellular Reprogramming. J Am Heart Assoc. 2020 Jun 16;9(12):e015686. doi: 10.1161/JAHA.119.015686. Epub 2020 Jun 5. PMID: 32500803; PMCID: PMC7429035.
  25. Mathison M, Singh VP, Chiuchiolo MJ, Sanagasetti D, Mao Y, Patel VB, Yang J, Kaminsky SM, Crystal RG, Rosengart TK. In situ reprogramming to transdifferentiate fibroblasts into cardiomyocytes using adenoviral vectors: Implications for clinical myocardial regeneration. J Thorac Cardiovasc Surg. 2017 Feb;153(2):329-339.e3. doi: 10.1016/j.jtcvs.2016.09.041. Epub 2016 Sep 23. PMID: 27773576; PMCID: PMC5297447.
  26. Mathison M, Sanagasetti D, Singh VP, Pugazenthi A, Pinnamaneni JP, Ryan CT, Yang J, Rosengart TK. Fibroblast transition to an endothelial "trans" state improves cell reprogramming efficiency. Sci Rep. 2021 Nov 19;11(1):22605. doi: 10.1038/s41598-021-02056-x. PMID: 34799643; PMCID: PMC8604927.
  27. Mathison M, Singh VP, Sanagasetti D, Yang L, Pinnamaneni JP, Yang J, Rosengart TK. Cardiac reprogramming factor Gata4 reduces postinfarct cardiac fibrosis through direct repression of the profibrotic mediator snail. J Thorac Cardiovasc Surg. 2017 Nov;154(5):1601-1610.e3. doi: 10.1016/j.jtcvs.2017.06.035. Epub 2017 Jun 21. PMID: 28711329; PMCID: PMC5647235.
  28. Mathison M, Gersch RP, Nasser A, Lilo S, Korman M, Fourman M, Hackett N, Shroyer K, Yang J, Ma Y, Crystal RG, Rosengart TK. In vivo cardiac cellular reprogramming efficacy is enhanced by angiogenic preconditioning of the infarcted myocardium with vascular endothelial growth factor. J Am Heart Assoc. 2012 Dec;1(6):e005652. doi: 10.1161/JAHA.112.005652. Epub 2012 Dec PMID: 23316332; PMCID: PMC3540681.